One Times Square, the famous building on the south end of Manhattan's Times Square, was once the home of The New York Times. Completed in 1904, and the Times stayed there for just 10 years before moving to a larger location. Over the next century, the building would become a home to a speakeasy, a shooting range, and offices, only to become mostly empty in recent years, undesirable due to all windows being obstructed by billboards. Despite the empty interior, it is still one of the most famous buildings in the world, housing the New Years Eve Ball, the focal point of the celebration in NYC.
Here is a Google StreetView of how the building looks today from approximately the same angle:
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